Recent experimental researches supports the hypothesis that mechanical stimuli play a role in regulating specialized molecules expression in articular cartilage in vitro and in vivo. Therefore we are studying bioreactor to provide a stimulus of mimicked real knee environment. Our bioreactor system consists of a joint motion stimulation device and culture chamber. We fabricated a stimulation system similar to movement of the CPM(Continuous Passive Motion) device for human joint motion. This system is composed of a linear stage, ball spline and links. Also we fabricated a culture system for media and circulation and mimicked knee environment. However, Previous culture system has some problems that media leakage and interference of joint model. In this study, we improved a new-chamber system for non-interference of joint model and medium sealing. Then, this system could be used to investigate the effect of dynamic culture.

Abstract
 1. 서론
 2. 무릎관절운동을 모사한 구동 시스템
 3. 무릎관절운동을 모사한 챔버 시스템
 4. 결론
 References

• 이승재(원광대학교 기계자동차공학부) | SeungJae Lee
• 김소연(원광대학교 기계공학과(원)) | So-Youn Kim
• 지민희(원광대학교 기계자동차공학부) | Min Hee Jee