Purpose: We conducted phenomenological qualitative research to provide in depth understanding on infectious disease management. Methods: Participants were 10 nurses working in an isolation ward, where only patients with infectious diseases were institutionalized in one general hospital in Seoul. Data were collected through individual interviews and analyzed according to Colaizzi data analysis method. Results: The main theme of the experience of the nurses who worked in the isolated ward was ‘Nurse's sense of duty to overcome the fear of infection’. Through 83 meaningful re-statements and 13 themes, three sub-themes including ‘Unstable isolation ward’, ‘Taking care of infected patients’ and ‘Insufficient isolation patient care system’. Conclusion: Nurses, working in the new isolation ward, work in a lonely and dangerous environment having fear of infection, being lack of supplies and overcoming various psychological difficulties. In-depth understanding of these needs require efficient infection management policies, measures, and societal recognition.