논문 상세보기
pp.493-504
Gastrodia elata Bl. (GE) is a traditional herbal medicine used for the treatment hypertension and cerebrovascular disease. The purpose of this study was to investigate the antioxidant effect and blood pressure control ability of the GABA containing fermented Gastrodia elata Blume. The fermentation strain provided by Dr. Gi in Seoul National University is L. brevis GABA100, excellent strain of GABA production, which is involved in the ability to degrade gastrodin glycosides and activation of brain function. The Gastrodia elata Blume fermented by Lactobacillus brevis GABA 100 showed antioxidant activity (total phenolic contents, DPPH radical and ABTS anion scavenging activities) than unfermented Gastrodia elata Blume. In the spontaneously hypertensive rats (SHR), the concentration of fermented Gastrodia elata Blume was administered at 500, 1,000, and 2,000 mg/kg for 8 weeks. Systolic blood pressure decreased statistically significantly (p<0.05), especially 2 weeks after feeding fermented Gastrodia elata Blume. Also, it showed a significant decrease in low, medium, and high concentrations of fermented Gastrodia elata Blume at 4 weeks and 8 weeks. These results indicated that Gastrodia elata Blume fermented by the excellent strain of GABA production L. brevis GABA100 shows the antioxidant function and the effect of suppressing the increase in blood pressure.
서 론
재료 및 방법
1. L. brevis G100 유산균을 이용한 발효천마
2. 총 페놀 함량
3. DPPH 라디칼 소거능 분석
4. ABTS 양이온 라디칼 소거능
5. 발효천마의 혈압조절능력 분석
6. 혈압측정 및 생화학적 분석
7. 통계처리
결과 및 고찰
1. 천마와 발효천마의 총 페놀 함량
2. DPPH 라디칼소거능 및 ABTS 양이온 소거능
3. 발효천마섭취에의한체중변화, 식이섭취및장기무게
4. 발효천마 섭취에 의한 고혈압 관련인자 변화
5. SHR 쥐에서 발효천마 섭취에 의한 심장비대 및 혈장내 생화학적 검사
요약 및 결론
References
