In this study, we learned about the effects of indoor radon concentration reduction associated with the operation of a mechanical ventilation system at an apartment house. The experimental parameters were mainly the indoor radon level and air change rate, which were controlled by the amount of emissions released and fan motor speed. Even at the high level of radon diffused in an apartment house, indoor radon concentrations converged to the Korean national guideline level within 3 to 4 hours when the air was ventilated at 0.5 ACH and 0.7 ACH. In the case of 0.3 ACH, however, where the degree of ventilation was insufficient compared to the legal air change rate, the high concentration indoor radon could not be sufficiently removed even if the mechanical ventilation system was operated for more than 14 hours continuously. When the indoor radon level was high, the reduction rate was 34.3% for 0.3 ACH, 70.4% for 0.5 ACH, and 69.7% for 0.7 ACH at 6 hours-operation, while at the medium-level, indoor radon can be reduced by 46.2% (0.3 ACH) to 73.2% (0.7 ACH). Depending on the indoor concentration range, it may be required to secure a ventilation rate of 0.5 ACH or more at all times. In addition, in apartment houses with excellent airtight performance, even if indoor radon is at a level similar to the national guideline, it is difficult to expect a reduction in the concentration due to natural decay. Therefore, it is desirable to lower the indoor concentrations as much as possible.