This study evaluated whether fevernill, which is primarily composed of acetaminophen, vitamin C, and anhydrous citric acid, is effective in relieving stress caused by foot-and-mouth disease virus (FMDV) vaccination in calves. Three-month-old calves from a farm in Korea were randomly assigned to one of three groups (n = 10 per group: control [untreated], group A [FMDV vaccination], and group B [FMDV vaccination + addition of fevernill 0.2% to feed for five days after vaccination]). Body weights, antibody formation, clinical symptoms, serum parameters were measured in the 14 days following vaccination. Total weight gain and average daily gain during the experiment period were group A (12.00±1.15 kg, 0.86±0.08 kg/day) compared to group B (13.57±0.98 kg, 0.97±0.07 kg/day) was significantly improved (p<0.05). There was no significant difference in the formation of antibodies against the FMDV vaccine between group A and group B, though the antibody value of group B tended to be higher than that of group A. The pre-inflammatory cytokine TNF-α value was 74.47±19.26 pg/ml in group A and 59.05±11.88 pg/ml in group B on the 5th day of the experiment, which was significantly lower in group B than in group A (p<0.05). Also, cortisol concentrations were significantly lower in group B than in group A (p<0.05). In conclusion, the feeding of fevernil is judged to be helpful in mitigating the side effects caused by FMD vaccination, and thus it is thought to be able to prevent the decrease in productivity caused by vaccination.

ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
    1. 공시재료
    2. 공시동물
    3. 백신접종
    4. 스트레스 완화 효과 지표
    5. 통계처리
Ⅲ. 결과
    1. FMD 백신 스트레스 완화 효능
Ⅳ. 고찰
Ⅴ. 요약
Ⅵ. 참고문헌

• 오우현(강원대학교 수의과대학 및 동물의과학연구소 대학원생, (주)한풍산업 학술팀 전무이사) | Woo-Hyun Oh (Graduate Student, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea , Executive Director, HAN POONG IND. CO., LTD., Incheon 21700, Korea.)
• 양송이(강원대학교 수의과대학 및 동물의과학연구소 대학원생) | Song-Yi Yang (Graduate Student, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea)
• 조영준(강원대학교 수의과대학 및 동물의과학연구소 대학원생) | Yong-Jun Cho (Graduate Student, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea)
• 이성진(강원대학교 동물응용과학과 교수) | Sung-Jin Lee (Professor, Department of Animal Industry Convergence, Kangwon National University, Chuncheon 24341, Korea)
• 한정희(강원대학교 수의과대학 및 동물의과학연구소 교수) | Jeong-Hee Han (Professor, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea) Corresponding author