Bovine rotavirus (BRV) is one of the common gastrointestinal diseases that can occur in calves, causing severe diarrhea. This study was conducted to investigate the effects of oral administration of single-domain antibodies, single variable domain of heavy chain of HCAb (VHH), on the prevention and treatment of rotavirus-induced diarrhea in calves. Thirty calves were divided into five experimental groups (negative control, positive control, group A, group B and group C). Except for the negative control group, the experimental groups were inoculated with BRV on the 4th day after birth. The VHH supplementation groups were fed with a substitute milk containing different concentrations of VHH (1%, 2.5% and 7.5%). Changes in body weight, clinical symptoms, serum antibodies, and virus detection in feces were observed for a total of 10 days in each experimental group. The results showed a higher survival rate in the VHH supplementation groups compared to the positive control group. Clinical symptoms caused by rotavirus were alleviated in the VHH supplementation groups. The detection rate of rotavirus in feces also decreased. Gross findings indicated that the severity of disease in the VHH supplementation groups was milder than that in the positive control group. Therefore, VHH could be proposed as a useful alternative for the prevention and treatment of rotavirus-induced diarrhea in calves.

대학은 끊임없이 새로운 지식을 만들고 기술혁신을 통하여 가치를 생산하는 핵심 기관이다. 본 연구에서는 삼중나선모델(Triple Helix Model)의 변화와 진화를 제시하고자 한다. 이를 위해 선진기술의 습득과 소화, 개선과 추월을 통한 과정에 요구되었던 다양한 인력양성 육성과 정책분석의 질적연구를 활용하였다. 1960년대는 기능공과 기술공 위주로 기능적역량이, 1980년 대와 1990년대는 대학원제도가 정착, 고급 인력양성과 함께 정부주도의 대학-기업연구소와의 Triple Helix Model (THM) 혁신활동에 필요한 기능과 기술역량의 인력양성이 강조되었다. 2000년대는 첨단․신산업에 요구되는 창의적 인재양성으로 진화하였고 대학 중심 THM이 본격적으로 추진되는 연구역량이 요구되었고 2010년 이후 창의와 융합역량의 인력양성 방향 성을 대학스스로 결정하는 큰 변화로 진화하였고, 이에 본 연구에서는 창조와 융합 인력양성의 지속적 수행을 위한 혁신모델로 ‘삼중나선싱크로시나리오모델’을 제시한다. 대학은 자유롭게 문제를 찾아내고 정부는 신기술을 위한 지원과, 개인경험과 기업문제를 하나의 시나리오로 엮어 이를 해결하고자 하는 도전의 장이 되어 끊임없는 혁신을 견인해야 한다.

본 연구는 아세트아미노펜, 비타민 C, 무수 구연산으로 구성된 해열진통 및 염증 완화제, 피버닐산의 사료첨가가 구제역(FMD) 백신의 접종으로 야기 될 수 있는 돼지의 부작용에 대한 감소 효과를 확인하기 위해 실시되었다. 8-9주령의 돼지(LYD) 30마리를 공시, 대조군(n=10), 구제 역 백신 접종군(n=10; T1), 구제역 백신+피버닐 산 투여군 (n=10; 백신 접종 후 5일 간 0.2% 피버닐 산 경구 투여, T2), 3개 그룹으로 배치하여 시험을 진행하였다. 각 시험 구에서 총 14일 동안 체중, 혈액학치, 혈액화학치, FMD 항체 및 스트레스 지표의 변화를 관찰했으며, 총 증체량 은 T1(11.13±1.33kg)에 비해 T2(13.76±1.73kg)에서 유의적 으로 증가하였다(p<0.001). 혈액학치 및 혈액화학치 분석 결과, 백신을 접종한 두 처리군에서 유의한 차이는 없었 다. FMD 항체 역가는 T1(89.1±7.9)에 비해 T2(91.9±5.6)에 서 증가하는 경향을 보였으나 통계적 유의성을 나타나지 않았다. T2 그룹의 코르티솔, TNF-α 및 CRP와 같은 스 트레스, 염증 지표 물질은 구제역 백신 접종 후 3일에서 5 일 사이에 각각 310.31±44.11ng/mL, 59.05±11.88pg/mL, 29.05±2.84ng/mL으로 T1(361.58±58.74ng/mL, 74.47±19.26 pg/mL, 34.21±5.34ng/mL)보다 유의적으로 낮게 측정되 었다. 시험 14일째에 육안 및 조직병리학적 분석 결과, 주 사 부위의 염증 반응은 T2에서 적게 관찰되었으며 염증세 포 침윤 및 섬유조직이 증식된 육아종성 염증 또한 T2에 서 적게 관찰되었다. 본 연구결과로 미루어 보아 피버닐 산의 0.2% 경구 투여는 체중감소, 발열 등의 임상증상을 감소시키는 효과가 있으며, 접종 부위의 염증반응을 억제 하여 구제역 백신 접종의 부작용에 대한 스트레스를 경감 시키는 것으로 판단된다. 따라서 백신 접종 후 피버닐 산 의 0.2% 경구 투여는 돼지에서 구제역 백신 접종과 관련 된 부작용을 줄이는 데 효과적인 것으로 사료된다.

Newborn piglets are routinely subjected to several treatments shortly after birth, one of which is tail-docking. Tail-docking, which is carried out without an anesthetic when the piglet is 3 to 4 days old, is intended to prevent the severe injuries that can occur when pigs bite each other’s tails. The study was performed in slaughterhouses to determine how much tail-docking prevented tail-biting and how much it caused clinical problems such as amputation neuroma. One thousand pigtails were collected from 3 slaughterhouses in different provinces and tail length and tail-biting injuries were examined. Among them, 659 tail tissues were examined for clinical problems like amputation neuroma. The collected tails were divided into 3 groups according to the length of the tail, which was defined as long (n=136, 75% of the tail remained compared to the referred intact tail length of 30.6±0.6 cm of crossbred Landrace×Yorkshire dam×Duroc sire; LYD), medium (n=694, 50% of the tail remained), and short (n=170, 25% of the tail remained). The results showed that 4.3% of 1000 tails had biting injuries and 58.7% of 659 tails had amputation neuromas. There was no significant association between the tail-biting injury and tail lengths (p=0.953). However, the tail-biting injuries differed significantly by the province (p<0.001), and the frequency of amputation neuromas also appeared more frequently in longer tail lengths (p<0.001). The results indicated that tail-biting behavior was not influenced by tail-docking but might be influenced by the housing system and/or management practices.

This study evaluated whether fevernill, which is primarily composed of acetaminophen, vitamin C, and anhydrous citric acid, is effective in relieving stress caused by foot-and-mouth disease virus (FMDV) vaccination in calves. Three-month-old calves from a farm in Korea were randomly assigned to one of three groups (n = 10 per group: control [untreated], group A [FMDV vaccination], and group B [FMDV vaccination + addition of fevernill 0.2% to feed for five days after vaccination]). Body weights, antibody formation, clinical symptoms, serum parameters were measured in the 14 days following vaccination. Total weight gain and average daily gain during the experiment period were group A (12.00±1.15 kg, 0.86±0.08 kg/day) compared to group B (13.57±0.98 kg, 0.97±0.07 kg/day) was significantly improved (p<0.05). There was no significant difference in the formation of antibodies against the FMDV vaccine between group A and group B, though the antibody value of group B tended to be higher than that of group A. The pre-inflammatory cytokine TNF-α value was 74.47±19.26 pg/ml in group A and 59.05±11.88 pg/ml in group B on the 5th day of the experiment, which was significantly lower in group B than in group A (p<0.05). Also, cortisol concentrations were significantly lower in group B than in group A (p<0.05). In conclusion, the feeding of fevernil is judged to be helpful in mitigating the side effects caused by FMD vaccination, and thus it is thought to be able to prevent the decrease in productivity caused by vaccination.

본 연구는 규모가 작고 역동적인 벤처기업의 성장에 영향을 줄 수 있는 요인들 중에서 기업의 전략적 행동이나 경영자의 경영 역량과 관련된 제품 전략과 CEO(최고경영자) 특성의 효과를 실증적으로 분석하였다. 벤처기업의 표본을 이용하여 FGLS 추정법에 기반한 회귀분석의 결과에 따르면, 제품 전략과 CEO 특성은 기업 성장에 유의한 영향을 주며 추가적인 설명력을 가진다. 일반적으로 제품의 다양화와 마케팅을 강조할수록, 변화혁신을 완화할수록 성장률이 높았다. 그리고 CEO가 경영지배력을 가진 창업자가 아니거나, 현재 사업관련 분야에서 실무경험이 많을수록 성장률이 높았다. 또한, 연구개발 위주 업무경력보다 일반경영 중심의 업무경력을 가진 CEO가 관리하는 기업이 성장률이 더 높았다. 제품 전략과 CEO 특성이 벤처기업의 성장에 미치는 이런 효과들은 조직수명주기 단계에 따라서 달라졌다. 창업기 및 초기 성장기에 있는 기업에서 제품의 마케팅 강조 전략과 CEO의 일반경영 중심 업무경력이 기업 성장에 미치는 긍정적 효과가 상대적으로 강화된 반면, 성숙기 및 정체기에 있는 기업에서 이런 제품 전략과 CEO 특성이 기업 성장에 미치는 효과가 부정적이거나 유의하지 않았다.

Twenty three samples of man-made mineral fibers (MMMF) were collected and analyzed for their mineral contents using a transmission electron microscope equipped with energy dispersive X-ray analyzer (TEM-EDX). Five glass fibers showed a straight fiber type without branches with average diameter ranged from 2.6㎛ to 5.6㎛ and average length 12.2∼29.6㎛. The major atomic compositions of the glass fibers were Na, Mg, Si, Ca, and Fe with a little variance among them and contained trace amounts of Al and Si. Eleven rock wool fibers also showed a straight fiber type without branches. The rock wool fibers used in 3 insulation panel and 1 insulation tube had average diameter 13.6∼26.4㎛ and average length 13.6∼26.4㎛. The major atomic compositions of the rock wool fibers were Na, Mg, Al, Si, S, Ca, Fe, and Cu with a little variance among them. Two of rock wool sealant fibers and one of coating material fibers had average 0.8∼ 2.2㎛ diameter and 9.9∼16.2㎛ average length. The major atomic compositions of the fibers were Mg, Al, Si, Ca, and Fe with a little variance among them and contained trace amount of S. The fibers in the rock wool coating materials contaminated partially with another type of fibers. Four of rock wool ceiling board showed 0.9∼2.04㎛ average diameter and 4.3∼15.2㎛ average length. The major atomic compositions of the fibers were Mg, Al, Si, S, Ca, and Fe with a little variance among them and contained trace amounts of Na, K, and Ti. Three of long glass fibers showed a mass appearance with finely splitted fibers, and the major atomic compositions of the fibers were Na, Mg, Al, Si, S, Ca, and Fe with no variance among them. One type of ceramic fiber showed 2.9±1.59㎛ average diameter and 20.3±9.38㎛ average length. The major compositions of the fibers were Al, Si, and S. A gypsum board and a perlite and a calcium silicate insulation material all showed aspect ratio less than 3:1, indicating non-fibrous materials. The major compositions of the gypsum board particles were Al, Si, S, K, Ca, and Fe, The perlite particles were consisted of Na, Al, Si, S, K, Ca, and Fe, and the calcium silicate insulation materials were mainly consisted of Al, Si, Ca, and Fe.

140 buildings of Korean major cities were investigated for the presence of asbestos and man made mineral fibers (MMMF) in their construction materials. 73 (52%) and 84 (60%) buildings contained asbestos and MMMF in their construction materials, respectively, and 17 (12%) buildings contained both asbestos and MMMF. 75% of the asbestos containing buildings were mostly constructed during 1970's. 100% of underground shopping arcades, 90% of manufacturing workplaces, 84% of train and bus terminals had the asbestos containing construction materials. The manufacturing workplaces of Daejeon (89%) and Daegu (89%), which mostly had been built in the past, used asbestos containing building materials, while the building in Seoul, Busan and Jinju, which were constructed recently, used relatively lower asbestos containing building materials with 46%, 28%, and 33%, respectively. 9 building materials that have been widely used in Korea were analyzed using a transmission electron microscope equipped with energy dispersive X-ray analyzer (TEM-EDX) for their mineral contents. All asbestos fibers showed typical characteristics of chrysotile fibers with hollow tube structure. The average diameter ranged from 0.03㎛ to 0.05㎛, and the average length were ranged from 7.5㎛ to 12.0㎛. Atomic percentages of asbestos fibers were 51.9∼55.9% of Mg, 41.3∼44.3% for Si, and 2.7∼4.8% for Fe.