제3형 자가면역성 췌장염은 면역관문억제제 치료와 관련된 새로운 형태의 췌장염으로 CD8+ T세포 중심의 면역 반응이 병태생리의 핵심이다. 환자의 약 2/3는 무증상이지만 일부는 상복부 통증 등 전형적인 증상을 보이며 진단은 면역관문 억제제 치료력, 효소 상승, 영상 소견 및 다른 원인의 배제로 이루어진다. 치료는 증상과 중증도에 따라 보존적 치료부터 스테로이드까지 다양하나 스테로이드의 장기 효과는 불확실하다. 1년 이내 췌장 위축이 절반 이상에서 발생하며 내분비·외분비 기능 저하로 이어질 수 있다.

Newborn piglets are routinely subjected to several treatments shortly after birth, one of which is tail-docking. Tail-docking, which is carried out without an anesthetic when the piglet is 3 to 4 days old, is intended to prevent the severe injuries that can occur when pigs bite each other’s tails. The study was performed in slaughterhouses to determine how much tail-docking prevented tail-biting and how much it caused clinical problems such as amputation neuroma. One thousand pigtails were collected from 3 slaughterhouses in different provinces and tail length and tail-biting injuries were examined. Among them, 659 tail tissues were examined for clinical problems like amputation neuroma. The collected tails were divided into 3 groups according to the length of the tail, which was defined as long (n=136, 75% of the tail remained compared to the referred intact tail length of 30.6±0.6 cm of crossbred Landrace×Yorkshire dam×Duroc sire; LYD), medium (n=694, 50% of the tail remained), and short (n=170, 25% of the tail remained). The results showed that 4.3% of 1000 tails had biting injuries and 58.7% of 659 tails had amputation neuromas. There was no significant association between the tail-biting injury and tail lengths (p=0.953). However, the tail-biting injuries differed significantly by the province (p<0.001), and the frequency of amputation neuromas also appeared more frequently in longer tail lengths (p<0.001). The results indicated that tail-biting behavior was not influenced by tail-docking but might be influenced by the housing system and/or management practices.