The detection of the genome-based antibiotic resistance gene is an essential analysis process for the purpose of verifying the safety of probiotic strains, including lactic acid bacteria. In this study, 4 analysis platforms (AMRFinderPlus, staramr, rgi, ABRicate) were used for cross-comparison of 782 genomes corresponding to 19 kinds of probiotic species notified as functional foods. As a result of the analysis, the relatively fewest number of antibiotic resistance genes were detected in strains belonging to the order Lactobacillales, and antibiotic resistance genes were detected in 322 genomes used in the case of 2 types of Enterococcus genus. In addition, the presence and type of antibiotic resistance gene detection showed a lot of difference even for the same genome sequence depending on the database and analysis algorithm used by the analysis platform. These results can be confused in evaluating the potential for transmission of antibiotic resistance genes inherent in specific lactic acid bacteria and predicting potential risks that may occur in the future. Accordingly, it is judged that the antibiotic resistance gene-related analysis criteria need to be established more clearly and specifically in the safety evaluation of probiotic bacteria.

Abstract
서 론
재료 및 방법
    사용된 유산균의 유전체
    항생제 저항성 유전자의 분석
결 과
    각 종별 항생제 저항성 유전자의 검출 유무
    분석 프로그램에 따른 항생제 저항성 유전자 검출의 차이
고 찰
    유전체 기반 항생제 유전자 검출 플랫폼별 분석결과의 차이
    항생제 저항성 유전자 분석 기준의 필요성
    Enterococcus 계열 사용의 적정성
References

• 곽우리(후니젠) | Woori Kwak (Hoonygen, Seoul 08592, Republic of Korea)
• 김병용((주)종근당건강) | Byung-Yong Kim (Chong Kun Dang Healthcare) Corresponding author