The study investigated the potential effect of the Ecklonia cava extract by using Jeju lava seawater (ECE-JLS; hardness: 100, 300 mg/L), which is naturally filtered underground by a volcanic rock layer. The chemical composition, antioxidant-related enzyme activities, radical scavenging activities, reactive oxygen species (ROS) production in Vero cells, and nitric oxide (NO) production in Raw 264.7 cells were measured to evaluate the antioxidant and anti-inflammatory activities of the extract. The total polyphenol and flavonoid contents of ECE-JLS100 and 300 were 156.41± 1.15, 166.16±2.27 mg/g, and 343.76±2.40, 373.90±3.67 mg/g, respectively. The concentration of ECE-JLS’ SOD and CAT-like activities was increased. ECE-JLS in the range of 0.25 to 2 mg/mL exhibited remarkable DPPH radical and hydrogen peroxide scavenging activities. ECE-JLS100 and 300 inhibited total ROS generation by 21.4±0.4 and 23.9± 0.3% in H2O2-induced Vero cells at 200 g/mL concentration, respectively. ECE-JLS100 and 300 decreased NO production, with levels of about 55.0±2.4 and 56.5±1.8% at 200 g/mL concentration, respectively. The contents of TNF-  were decreased compared to the negative control. These observations provide helpful information for the potential industrial use of Jeju lava seawater. Also, ECE-JLSW could be used as a functional food material.

Abstract
서 론
재료 및 방법
결과 및 고찰
요 약
감사의 글
References

• 이연지(한국해양과학기술원 제주특성연구센터) | Yeon-Ji Lee (Jeju Marine Research Center, Korea Institute of Ocean Science Technology (KIOST))
• 박아름이(한국해양과학기술원 제주특성연구센터) | Areumi Park (Jeju Marine Research Center, Korea Institute of Ocean Science Technology (KIOST))
• 강나래(한국해양과학기술원 제주특성연구센터) | Nalae Kang (Jeju Marine Research Center, Korea Institute of Ocean Science Technology (KIOST))
• 강도형(한국해양과학기술원 원장실) | Do-Hyung Kang (Office of The President, Korea Institute of Ocean Science Technology (KIOST))
• 허수진(한국해양과학기술원 제주특성연구센터) | Soo-Jin Heo (Jeju Marine Research Center, Korea Institute of Ocean Science Technology (KIOST)) Corresponding author