This paper proposes a method to evaluate the structural safety of a large wide-width greenhouse structure against wind load caused by a typhoon through a fluid structure interaction analysis technique. The conventional method consisted of roughly estimating the wind load based on the relevant laws and regulations, and determining safety through structural analysis. However, since the wind load changes nonlinearly according to the wind speed distribution and wind direction around the greenhouse and the external shape of the structure, there are many uncertainties in the existing structural safety evaluation method, and it is difficult to accurately determine the design margin. In this study, a systematic method was developed to accurately calculate the wind load acting on a greenhouse structure and evaluate structural safety by considering the characteristics of wind through a fluid structure interaction analysis using coupled computational fluid dynamics and computational structural mechanics. Using the proposed method, it is possible to significantly reduce the manufacturing cost because it is possible to obtain an optimal design that reduces the over-conservative design margin while securing the structural strength of the greenhouse.