논문 상세보기
pp.108-113
Sprague-Dawley 흰쥐에 고지방식이로 6주간 식이하면서 천궁 열추출액을 경구투여하여 혈장 중 GOT, GPT 및 LDH 활성과 지방의 분해와 합성에 관여하는 코티졸과 인슐린의 함량을 측정하였다. 또한 지방침착억제효과를 광학현미경으로 관찰하였다. GOT, GPT 및 LDH의 활성은 정상군보다 높았으나 대조군보다 낮았으며 현미경 관찰을 통하여 지방간이 약간 개선되고 있음을 나타내어 천궁의 투여가 고지방식이에 의한 비만유발의 개선효과의 경향을 나타내었다.
This study was carried out to evaluate the effect of Cnidi rhizama(CR) water extract on fat accumulation in fatted rats induced by the oral high fat administration for six weeks. To accomplish this evaluation, the serum and liver tissue have been examined for enzyme activity, cortisol and insulin level. The change of liver tissue have been observed by the light microscope. GOT, GPT and LDH activities were lower than the control group. Insulin and cortisol were higher than the control group, due to the fat accumulation. The liver of the control group observed by the light microscope appeared to the fatty liver, but CR group showed some improvement of the fatty liver. Based on the above results, it was shown that it is possible to improve fat accumulation induced by high fat dietary through using the oral administration of Cnidi rhizoma water extract.
