In a steam turbine system for nuclear power plant, the exhaust loss consists of leaving loss, hood loss, turn-up loss and restriction loss. The exhaust loss during rated power operation of steam turbine equipment is inevitable, but it can be optimized by several factors such as last stage blade length, condenser vacuum and steam velocity. In this paper the relationship between the exhaust loss and electrical output of domestic nuclear power plants was quantitatively evaluated, and ways to reduce this loss were considered.