Cardiovascular disease remains a leading global cause of mortality, demanding effective prevention and management. This systematic review explores the impact of lycopene, prevalent in various fruits, on cardiovascular health. Thirteen randomized and controlled trials were analyzed, involving 385 participants with cardiovascular risk factors. Notable findings included significant blood pressure reductions, particularly among hypertensive individuals, and favorable alterations in lipid profiles. Lycopene interventions also demonstrated potential in mitigating oxidative stress and inflammation markers. While these findings show promise, more rigorously designed studies are essential to determine optimal dosages and durations for precise cardiovascular benefits. In conclusion, lycopene shows potential in managing cardiovascular risk factors, and its role in blood pressure regulation, lipid profile improvement, and antioxidant and anti-inflammatory effects is encouraging. Nonetheless, further research is warranted to provide definitive guidance on integrating lycopene to enhance cardiovascular health.

Introduction
Materials and Methods
    Literature search
    Eligibility criteria
    Data extraction
    ‘Risk of Bias’ analysis
Results and Discussions
    Study selection
    Study characteristics
    ‘Risk of Bias’ assessment
    Lycopene on blood pressure
    Lycopene on blood lipid profiles
    Lycopene on oxidative stress and anti-inflammation
Conclusions

• Hye Ri Joung(Department of Food and Nutrition, Hanyang University)
• Gyoungok Gang(Department of Food Science and Nutrition, Pukyong National University)
• Gwang-woong Go(Department of Food and Nutrition, Hanyang University) Corresponding author