To decrease area of the repository for high-level radioactive waste, enhancing the disposal efficiency is needed for public acceptance. Previous studies regarding the performance assessment of KRS and KRS+ repository did not consider area-based variations of the geothermal gradient and rock thermal properties in Korea. This research estimated deposition hole spacing based on performance assessment of a repository using the distribution of geothermal gradient and rock thermal properties in Korea to increase disposal efficiency. Distributions of geothermal gradient, rock thermal properties were investigated based on 2019 Korea geothermal atlas published by Korea Institute of Geoscience and Mineral Resources (KIGAM). Effect of thermal performance parameters was analyzed using coupled thermal-hydraulic numerical simulations, and effect of rock thermal conductivity and deposition hole spacing on the maximum temperature of buffer was relatively large. In addition, distribution maps of thermal performance of a repository and deposition hole spacing were plotted using thermal performance parameters-maximum temperature of buffer regression equations and GIS data given by KIGAM. In the regions showing the highest maximum temperature of buffer in Korea, required deposition hole spacings were 10.5 m, 10.0 m, 10.1 m, respectively for KJ-II, MX-80, and FEBEX bentonite cases, and thereby additional disposal area of 40%, 33.3%, and 34.7% were required compared to that of the KRS+ repository. On the other hand, high disposal efficiency can be obtained in the regions showing the low maximum temperature of bentonite buffer. The methodology provided in this research can be used as one of the references for the selection of domestic candidate repository sites. Additional mechanical performance analysis should be conducted using distributions of mechanical properties of rock mass in Korea.