Acorns have been used as a traditional remed as well as food source. However, few studies on their immunomodulating effects have been reported. In this study, the combined immunomodulative effect。of a water extract of acorns was tested on seven to eight weeks old mice (baIb/c). The mice were fed ad libitum on a chow diet, and a water extract of the plant mixture was orally administered every other day for four weeks at two different concentrations (50 and 500mg/kg B. W.). The production of cytokine (lL-lβ, IL-6, IL-2, lL-10, IFN－r）, secreted by macrophages stimulated with LPS or not, detected by ELISA assay using cytokine kit. After 48 h of incubation with mitogen (ConA or LPS) ex vivo study showed that cytokine (IL-lβ, IL-6, IL-2, IL-10, IFN－r） was detected in both of the 50 and 500 mg/kg B. W. supplementation groups with LPS stimulation. The results of this study may suggest that supplementation with acom water extract increase immune function by regulating cytokine Production capacity by activated macrophages.

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