This study aims to present safety distances by the damage impact assessment of the leakage of propylene oxide. As a result of the experiment, the pressure 1psi range was 52m to 169m, the radiant heat 18kW/㎡ range was 63m to 163m, the AEGL-2 range was analyzed as 224m to 414m, and the fire ball diameter was analyzed to be 45m to 121m. Additionally, the extent of damages was proportional to the amount of propylene oxide stored or handled. The safe distance for a 10% lethality due to overpressure and radiant heat was calculated to be 134m, and the safe distance for a 0% lethality was 169m. Toxicity was measured at 134m with a lethality 0%. Therefore, the safety distance due to leakage of propylene oxide is calculated to be between 134m and 169m.