There are now many seismic observatory stations, excluding the acceleration monitoring network for infrastructures, of more than 300 operated by several public and governmental organizations across South Korea. The features of the site and properties of the stations were not investigated, and they have been assumed or guessed to estimate the site-specific seismic responses during the 2016 Gyeongju and 2017 Pohang earthquake events. For these reasons, various and intensive geotechnical and geophysical investigations have been conducted to quantify the site characteristics at 15 seismic stations selected in southeastern Korea. The VS profiles were, at first, obtained by performing only a downhole seismic test (DHT) at 7 stations, and were compared with those from a surface wave method. Then, the shear wave velocity (VS) profiles were deduced by combining three types of in situ seismic methods composed of a cross-hole seismic test, DHTs, and full-waveform sonic loggings at the 8 other stations, especially to complement the application limits of DHT and reduce the depth-dependent uncertainty in VS profile. The representative site characteristic profiles for each station regarding VS and VP with borehole stratigraphy and density were determined based on robust investigations. Various site parameters related to seismic responses at the seismic stations of interest were obtained for the site-specific geotechnical information, which would be useful to earthquake engineering practices.