This study was conducted to verify the impact of hazardous risk factors in manufacturing workplaces on worker safety behaviors, focusing on the mediating effect of safety climate, and to establish safety management strategies in manufacturing workplaces and to suggest practical measures to improve worker safety. For this study, the results of the ‘10th Occupational Safety and Health Survey’ conducted by the Korea Occupational Safety and Health Agency’s Occupational Safety and Health Research Institute in 2021 were used as analysis data for 3,255 manufacturing workplaces with 20 or more regular workers. The data were analyzed using the SPSS 24.0 program for descriptive statistical analysis, validity and reliability verification, correlation and multiple regression analysis, and hierarchical regression analysis. As a result of the study, first, hazardous risk factors were confirmed to have a negative effect on workers' safety behaviors. Second, hazardous risk factors were confirmed to have a negative effect on safety climate. Third, safety climate was confirmed to have a positive effect on workers' safety behaviors. Fourth, it was verified that the safety climate had a partial mediating effect in the relationship between hazardous risk factors and workers’ safety behavior in the workplace. Through this study, it was found that hazardous risk factors had a negative effect on workers’ safety behavior. This emphasizes that efforts to systematically manage and minimize hazardous risk factors in the workplace are important in promoting workers’ safety behavior. In addition, it was confirmed that the safety climate had an important mediating effect in the relationship between hazardous risk factors and workers’ safety behavior. In other words, it can be seen that the safety climate can alleviate the negative effect of hazardous risk factors on workers’ safety behavior. These research results suggest that reducing hazardous risk factors in the workplace and improving the safety climate can have a positive effect on workers’ safety behavior practice, thereby preventing industrial accidents.