Indoor air quality is a critical factor affecting health and quality of life, especially in spaces frequently used by sensitive populations such as adolescents. This study assessed the impact of garden ball installations and electrochemical fertilizer applications on indoor air quality in two youth centers, Center S and Center W, located in Bucheon, South Korea. PM2.5, PM10, and CO2 concentrations were monitored and analyzed based on the presence of garden balls and the use of electrochemical fertilizers. The results showed that spaces with garden balls (w/ G.B.) had significantly lower PM2.5 and PM10 concentrations compared to offices and spaces without garden balls (w/o G.B.). In Center W, the presence of garden balls alone improved air quality, highlighting the potential of vertical greening as a sustainable solution. In Center S, the application of electrochemical fertilizers during the “after + period” (when both garden balls and electrochemical fertilizers were applied) further enhanced particulate matter reduction, demonstrating the fertilizers’ ability to amplify plants’ air-purifying effects. This study provides empirical evidence that garden balls are an eco-friendly option for indoor air quality management. Combining electrochemical fertilizers with garden balls shows promise for enhancing air quality, offering a practical model for multi-use facilities such as youth centers.