This study investigated the antidiabetic activity of Salvia plebeia 70% ethanol extract (SPEE) and S. plebeia water extract (SPWE). The effects of SPEE and SPWE on adipogenesis were evaluated using 3T3-L1 adipocytes. Oil Red O staining showed that SPEE inhibited adipogenesis in 3T3-L1 adipocytes. Both SPEE and SPWE were analyzed for their total polyphenol contents (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, and α-glucosidase inhibition. SPEE exhibited significantly higher TPC and DPPH radical-scavenging activities than SPWE. Next, an oral glucose tolerance test was performed to assess the potential hypoglycemic effects of SPEE in a streptozotocin (STZ)-induced diabetic mouse model. Blood glucose levels in STZ-induced diabetic mice decreased 30 min after treatment with SPEE (300 mg/kg) and SPWE (300 mg/kg). Therefore, this study provides a basis for further investigations into the clinical applications of SPEE as a preventative agent against diabetes.

Abstract
서 론
재료 및 방법
    시료 추출
    세포배양
    세포생존율 측정
    Oil Red O Staining
    총 폴리페놀 함량 측정(total polyphenol content)
    DPPH 라디칼 소거 활성
    α-Glucosidase Inhibition (%)
    실험동물 및 군 구성
    당뇨 유발
    경구당부하 검사(oral glucose tolerance test, OGTT)
    통계처리
결과 및 고찰
    3T3-L1 세포 생존율 측정 결과
    3T3-L1 세포에서 지방생성 억제 효과
    총폴리페놀 함량 측정 결과
    DPPH를 이용한 라디칼 소거 활성
    α-Glucosidase 효소 억제 효과
    경구당부하 검사 결과
요 약
References

• 이윤성(나인헬스케어(주)) | Yun-Seong Lee (Nain Healthcare Co., Ltd., Iksan 54613, Korea)
• 이보영(원광대학교 식품영양학과) | Bo-Young Lee (Department of Food and Nutrition, College of Agriculture and Food Sciences, Wonkwang University, Iksan 54538, Korea) Corresponding author