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Withdrawal period and time-dependent residues for the tetrachlorvinphos oral product in milk KCI 등재
- 언어KOR
- URLhttps://db.koreascholar.com/Article/Detail/445552
pp.122-129
This study was conducted to investigate the residue pattern in milk of tetrachlorvinphos oral product used in dairy cows and to suggest an appropriate withdrawal period for the tetrachlorvinphos oral product in milk. The oral product containing tetrachlorvinphos was administered per oral to Holstein dairy cows at a dose of 3.4 g of the active ingredient per 100 kg body weight (maximum dose). Milk was collected at 12-hour intervals during administration and up to 120 hours after termination of administration to determinate tetrachlorvinphos residue in milk by LC-MS/MS. Tetrachlorvinphos residues at each time point and the maximum residue level for tetrachlorvinphos in milk (0.01 mg/kg) were applied to a non-statistical model to establish the withdrawal period of the test product. The recovery, precision, coefficient of determination(R2), limit of detection (LOD) and limit of quantitation (LOQ) of the analytical methods used to quantify tetrachlorvinphos were 98%~104%, 5%~11%, 0.9981~ 0.9991 and 2 μg/kg, 7 μg/kg, respectively. These parameters met all the method validation criteria suggested by the Ministry of Food and Drug Safety and were used as an analytical method for tetrachlorvinphos in milk. When this product was administered to dairy cows at 1x dose by feeding, the tetrachlorvinphos was undetectable in milk (below the limit of detection) in all cows during the dosing period and up to 120 hours after termination of administration. Therefore, we suggest the withdrawal period of this product in milk as 0 days.
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재료 및 방법
시약 및 기기
표준원액 및 용액의 조제
시험동물
시험제품 투여 및 시료 채취
기기분석
시료 전처리
분석법 검증
결 과
분석법 검증
시료의 안정성
고 찰
감사의 글
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