논문 상세보기
A scoping review of obesity-related genetic studies using the Korean Genome and Epidemiology Study published in 2010–2025 KCI 등재
pp.1-10
Obesity is a multifactorial condition resulting from complex interactions between lifestyle factors and genetic predispositions. As genetic susceptibility to obesity differs across ethnic groups, identifying population-specific genetic markers is essential for effective obesity prevention and management. This study reviewed obesity-related genetic studies conducted in Korean populations to identify obesity-associated genetic predisposition markers in this population. An exploratory literature review was conducted on studies published between 2010 and 2025 that utilized data from the Korean Genome and Epidemiology Study (KoGES). A scoping review of 11 eligible studies, including two polygenic risk score studies and nine single nucleotide polymorphism-based studies, identified several genes associated with obesity in the Korean population, including FTO, CD36, ESR1, APOB, SPRY1, NPY, PDGFC, and CAB39. Although KoGES-validated markers have been partially incorporated into domestic genetic testing services, most services predominantly rely on genetic markers originally identified in Western populations. Only a limited number of obesity-associated genetic predisposition markers specific to the Korean population have been consistently validated, and these markers partially differ from those reported in non-Asian populations. Further large-scale KoGES-based studies are required to establish genetic markers optimized for obesity risk assessment in the Korean population.
Introduction
Materials and Methods
Scoping review procedure
Results
General characteristics of the studies
Analysis of research trends and topics
Single nucleotide polymorphisms
Polygenic risk score
Current status of obesity genetic testing services
Discussion
ORCID
Conflict of interests
Acknowledgements
Data availability
Authorship contribution statement
Ethics approval
References
