In order to examine toxic effect of Jangwonhwan on cultured mouse cerebral cortical neurons inhibited by neurotoxicity induced by Xanthine Oxidase/Hypoxanthine(XO/HX), MTT and lipid peroxidation assay were performed after cerebral cortical neurons were preincubated with various concentrations of Jangwonhwan water extract before treatment of cells with XO/HX. The result were as follows ; 1. XO/HX induced cell degeneration such as the decrease of cell viability was measured by MTT in the cultured mouse cerebral cortical neurons 2. Jangwonhwan water extract was effective in the decrease of lipid peroxidation of neurons produced by XO/HX. From the above results, it is suggested that Xanthine Oxidase/Hypoxanthine(XO/HX) induces the inhibition of cell viability in cultuerd mouse cerebral cortical neurons and Jangwonhwan was effective in cultured neurons damaged by XO/HX.

Nowadays because of social and structural complexities, patients in the field of Psychoneurosis tend to increase gradually. So it needs to be diagnosed and treated for neuroses regardless of Oriental-Western Medicine. The category about Psychosomatic disease of Psychosomatic Medicine which is studied at present, nevertheless, is seen to focused on the limited range that called neurotic state and studies of Psychosomatic Medicine is divided into the field of psychology, philosophy and medicine. To set up the foundation for the course of Psychosomatic Medicine and medical solution of Psychosomatic relation, I have considered, compared and contrasted between Stress theory and Seven modes of emotion theory which is well thought to reflect the Psychosomatic Medicine and I came to the conclusion as follows; 1. Stress theory has commons with Seven modes of emotion theory in mechanism and notion. First, Both-Stress and Seven modes of emotion theory- explain the changes of function in body. second, they both are the internal reactions. third, they bring about the morphologic disease directly through the functional path change. Finally, the reaction is not partial but general and synthetic. Four similarities above show that two theories are identical with respect to the important characteristics and mechanism. 2. Compared with Seven modes of emotion theory, Stress theory concentrates on only anger, anxiety, surprise out of Seven emotion modes and that was the part to be studied from now on. 3. Studies on Stress and Seven modes of emotion theory is the ones which makes clear the prospect and course of Psychosomatic Medicine. They provide the clue that can explain the relationship of mind and disease, emotion and body, and already established theory. So they developed the medical science from treatment-centered to prevention- centered.