This paper explores the effect of the digital economy on human migration in Guangdong Province. This paper measures the effect of digital economy development on human migration in 21 prefecture-level cities in Guangdong Province, China, from 2011 to 2019 using a fixed-effects model. The results of this study show that there is a significant positive effect of digital economy on net migration rate, and there is a significant negative effect on emigration rates. There is also a significant pull effect of economic development level and health-care level on migration. This finding holds after introducing instrumental variables estimation. This study provides explanatory mechanisms and empirical evidence for the development of digital economy and human migration, which helps to understand the mechanism of action between the development of digital economy and human migration. On this basis, this study puts forward policy recommendations, which provide some reference basis for the formulation of policies on digital economy and talent introduction in Guangdong Province.