By thermal-structural coupled stress analysis, the equivalent stress and total deformation of girder under the influence of the temperature of the liquid within pipeline of pipe-rack structure is studied. Firstly, steady-state thermal analysis is carried out using a commercial software. Then, to perform a thermal-structural coupled stress solution, structural analysis is linked to the thermal model at the Solution level. The simulation results showed that the stress ratio that considers the pipe’s temperature for thermal-structural coupled stress analysis is higher than the stress ratio that consider only the pipe’s weight for structural analysis. The thermal stress caused by temperature convection is found to be influential on the pipe rack structure.