In adults, the complications of measles are more fatal and the viremia lasts longer than in children. Reports on severe forms of measles in adults are rare and no cases of elderly adults who experienced multiple organ failure in Korea have been reported. A 68-year-old man with a rash, fever, cough, and conjunctivitis was admitted to our hospital and confirmed by positive expression of specific IgM antibody to measles. The patient experienced acute kidney injury and acute lung injury requiring renal replacement therapy and mechanical ventilation. Herein, we report on a rare case of measles showing multiple organ failure in an elderly adult.