의약품과 식품을 포함한 자연이나 환경속에 포함되어 있는 여러 가지 화학물질들은 암 및 돌연변이를 유발할 수 있기 때문에 이런 것들에 의한 유해작용을 줄이려 노력하고 있으나 완전히 없애기 어려운 현실이다. 따라서 식생활 습관을 개선하거나 식품내에 존재하는 발암억제물질을 이용하여 암의 발생된 위한 연구는 암의 치료제 개발과 더불어 관심의 대상ㅇ디 되고있다. 여러 가지 식품속에 자연적으로 함유된 ellagic acid는 항돌연변이와 함암역제 효과가 있는 것으로 잘 알려져 있다. 따라서 본 실험에서는 단기간 ellagic acid의 발암억제효과를 알아보기위하여 전암지표효소인 GST-P 양성중식소를 측정하였다. Diethylnitrosamine으로 간장에서 암을 유발하였고 phenobarbital과 간부분절제술로 암을 촉진시켰으며, ellagic acid를 400과 800ppm 투여근으로 구분하고 투여시기를 달리하여 실험하였다. 따라서 diethylnitrosamine으로 유발된 간장의 긴장의 발암은 ellagic acid에 의해 용량의존적으로 억제됨을 알 수 있다.

The association of colorectal cancer with ulcerative colitis (UC) is well-recognized. However, not much is known regarding the increased risk of extra-intestinal malignancies with UC. Several studies have revealed that patients with UC are at in-creased risk of hepatobiliary cancer, nonmelanoma skin cancer, and myeloid leukemia. A 41-year-old man was diagnosed with UC in 1993 and had three relapses over the next three years. Six months after the fourth remission, he developed pan-cytopenia and was diagnosed with acute promyelocytic leukemia (APL). He achieved complete remissions of APL through chemotherapies, and, since then, no recurrences of APL and UC were observed.

In adults, the complications of measles are more fatal and the viremia lasts longer than in children. Reports on severe forms of measles in adults are rare and no cases of elderly adults who experienced multiple organ failure in Korea have been reported. A 68-year-old man with a rash, fever, cough, and conjunctivitis was admitted to our hospital and confirmed by positive expression of specific IgM antibody to measles. The patient experienced acute kidney injury and acute lung injury requiring renal replacement therapy and mechanical ventilation. Herein, we report on a rare case of measles showing multiple organ failure in an elderly adult.

Idiopathic spontaneous intraperitoneal hemorrhage is a rare, often fatal condition; however, the patients present with nonspecific symptoms. Even after a comprehensive radiological examination and surgical exploration, the origin of hemorrhage often remains unclear. A 74-year-old woman with sudden abdominal pain, nausea, and vomiting was admitted to our hospital. She had no history of trauma. Computed tomography showed a huge hematoma along the small intestinal mesentery without evidence of visceral organ abnormality causing bleeding. The hematoma was completely removed by surgery and no origin of hemorrhage was detected. Herein, we report on a case of idiopathic spontaneous intraperitoneal hemorrhage.

Intramuscular lipoma is a rare benign tumor. It refers to infiltrating lipoma because it originates between skeletal muscle abundles and infiltrates into the intramuscular septa. Kransdorf reported that the majority of lipomas were located in the trunk, head/neck, and lower extremity. In addition, in research by Kindlom et al., on 43 cases of muscular infiltrative lipoma, there was no case involving the chest wall. We report on a case of intramuscular lipoma on the anterior chest wall. The lesion was removed completely and histopathological findings showed that mature adipocytes had infiltrated serratus anterior muscle in a diffuse manner. After treatment, the patient has shown no complication or evidence of recurrence.

This paper presents the estimation of the frictional coefficient of the wheel-legged robot with hip joint actuation producing maximum tractive force. Slip behavior for wheel-legged robot is analytically explored and physically understood by identification of the non-slip condition and derivation of the torque limits satisfying it. Utilizing results of the analysis of slip behavior, the frictional coefficients of the wheel-legged robot during stance phase are numerically estimated and finally this paper suggests the pseudo-algorithm which can not only estimate the frictional coefficients of the wheel-legged robot, but also produce the candidate of the touch down angle for the next stance.