Intramuscular lipoma is a rare benign tumor. It refers to infiltrating lipoma because it originates between skeletal muscle abundles and infiltrates into the intramuscular septa. Kransdorf reported that the majority of lipomas were located in the trunk, head/neck, and lower extremity. In addition, in research by Kindlom et al., on 43 cases of muscular infiltrative lipoma, there was no case involving the chest wall. We report on a case of intramuscular lipoma on the anterior chest wall. The lesion was removed completely and histopathological findings showed that mature adipocytes had infiltrated serratus anterior muscle in a diffuse manner. After treatment, the patient has shown no complication or evidence of recurrence.