This study is to conduct the optimal design of the fluid mixing blades in the test fluid tank for sewage treatment process. The design was made with various shapes and angles of mixing blades. Fluid mixing blades in the tank are numerically analyzed with FLUENT V.13.0. Blade1 and Blade4 had the biggest fluid pressure difference of 8.1% around the blades. And, Blade1 and Blade3 had the least fluid pressure difference of 2.55%. The biggest turbulence kinetic energy of 12.5% existed around Blade1 and Blade4. Blade1 and Blade3 had the least turbulent kinetic energy difference of 4.8%. Blade4 is the optimal design shape due to the highest turbulent kinetic energy around the blades in comparison to the other cases.