The study aim was to develop and test the effects of integrated simulation pertaining to patients with schizophrenia using a hypertensive crisis module for nursing students. Methods: This pilot study with seven undergraduate nursing students used a single group, pre-post test design. Integrated simulation pertaining to patients with schizophrenia using a hypertensive crisis module was developed based on the ADDIE model (i.e., Analysis, Design, Development, Implementation, and Evaluation), expert meetings with subject professors, a literature review, a preliminary survey, and focus group interviews. Data were collected and measured for general characteristics of the study participants, critical thinking disposition, problem-solving, clinical judgment, self-efficacy, simulation design, and simulation effectiveness. Qualitative contents were analyzed through focus group interviews. Results: No statistically significant differences were found in class design, critical thinking disposition, problem-solving, clinical judgment, and self-efficacy after applying the integrated simulation module. Based on the data obtained from the focus group interviews of study participants, the following four categories were established: “Integrating knowledge and applying it to practice,” “Nursing in unexpected situations,” “Challenged to be an expert,” and “Ensuring receptive and psychological safety in simulation practice.” Conclusion: An integrated simulation module was developed to integrate the nursing problems associated with individual subjects beyond the scope of one subject, and the effect was verified by applying it