A two-phase flow in mini-channels is consist with various flow regimes (such as bubble slug, annular, churn flow) according to gas and liquid phase flow rates. A previous researches revealed that in a case of slug flow in hydrophobic mini-channels, gas and liquid phase are perfectly separated by interfaces and triple contact line. In this study, the single dry slug flow experiments in circular mini-channel (D = 1.018 mm) are conducted to observe interfacial break-up phenomena in high capillary number range (Ca < 0.02). The slug is consist with D.I. water or D.I. water-ethanol binary mixtures (5% and 10%, mole fraction). On the base of previous researches, we calculate the pressure drop at moving triple contact line. In an addition, a single dry slug flow is visualized by using high-speed camera. Through the experiment, three regimes of pressure drop are observed; steady, loss, separation. As a result, criteria between steady and loss regimes is closely related to capillary number, and criteria between loss and separation regimes is related to surface tension.