In this study, we propose an optimal design method by applying the Prefabricated Buckling Restrained Brace (PF-BRB) to structures with asymmetrically rigidity plan. As a result of the PF-BRB optimal design of a structure with an asymmetrically rigidity plan, it can be seen that the reduction effect of dynamic response is greater in the case of arrangement considering the asymmetric distribution of stiffness (Asym) than in the case of arrangement in the form of a symmetric distribution (Sym), especially It was confirmed that at an eccentricity rate of 20%, the total amount of reinforced PF-BRBs was also small. As a result of analyzing the dynamic response characteristics according to the change in eccentricity of the asymmetrically rigidity plan, the distribution of the reinforced PF-BRB showed that the larger the eccentricity, the greater the amount of damper distribution around the eccentric position. Additionally, when comparing the analysis models with an eccentricity rate of 20% and an eccentricity rate of 12%, the response reduction ratio of the 20% eccentricity rate was found to be large.