Purpose: This study aimed to explore advanced response policies and psychological and emotional support measures for early infected people in the event of an infectious disease by analyzing the experiences of self-employed women who experienced confirmation in the early stages of the coronavirus disease 2019(COVID-19) pandemic. Methods: Data were collected through in-depth interviews with six experiences of self-employed women confirmed with COVID-19 in the early stages of the pandemic selected through the intentional sampling process, and then analyzed and interpreted through Interpretative Phenomenological Analysis (IPA). Results: Through analyzing the meaningful statement of the study participants, several themes were identified, including “The pressure of dying from an incurable illness”, “The fear of quarantine and the fear of death”, “The difficulty of being a self-employed woman”, “The pain of social stigma”, “The driving force of one’s overcoming”, and “Expansion of perspective due to new experiences”. Conclusion: The study found that participants experienced anxiety and fear during the transfer process and admission to the facility after confirmation, due to the lack of guidance and face-to-face interactions. The non-face-to-face treatment increased their anxiety, as they could not receive accurate information about their health conditions and care. This highlights the impact of inaccurate information regarding COVID-19 and media reports focusing on severely ill patients and deaths. In addition, the study participants experienced social stigma caused by COVID-19, resulting in changes in their interpersonal relationships and life attitudes. Implications are suggested based on the results of this study.