Diagnosis of chronic myelogenous leukemia (CML) and non-Hodgkins lymphoma (NHL) have rarely been made simultaneously in the same patient. We report a rare case of a patient with CML-chronic phase who developed a concurrent Philadelphia (Ph)-negative diffuse large B-cell lymphoma. At the time of diagnosis, cytogenetic analysis of peripheral blood and bone marrow cells revealed the Ph-chromosome translocation in all examined metaphases. A lymph node biopsy showed features of diffuse large B-cell lymphoma, and fluorescence in situ hybridization (FISH) of lymph node tissue for BCR-ABL was negative. The patient was treated with R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin and prednisone) and imatinib mesylate.

Infection is common in neutropenic patients who have hematologic malignancies. Pyomyositis forms abscesses in the skeletal muscle withStaphylococcus aureusas the most common pathogen. Patients with pyomyositis who also have hematologic malignancies are rare especially when the primary diagnosis was the malignancy. In addition, to the authors’ knowledge there are no reports of Pseudomonas species as the myositis pathogen.