In this study, we investigated the effects of precipitates and oxide dispersoids on the high-temperature mechanical properties of oxide dispersion-strengthened (ODS) Ni-based super alloys. Two ODS Ni-based super alloy rods with different chemical compositions were fabricated by high-energy milling and hot extrusion process at 1150℃ to investigate the effects of precipitates on high-temperature mechanical properties. Further, the MA6000N alloy is an improvement over the commercial MA6000 alloy, and the KS6000 alloy has the same chemical composition as the MA6000 alloy. The phase and microstructure of Ni-based super alloys were investigated by X-ray diffraction and scanning electron microscopy. It was found that MC carbide precipitates and oxide dispersoids in the ODS Ni-based super alloys developed in this study may effectively improve high-temperature hardness and creep resistance.