Anti-diabetic activities of cultured mycelia from Ganoderma applanatum are being evaluated in this study. The OGTT and 4-weeks of repeated oral efficacy tests are conducted in mice at the doses of 0 (vehicle treatment), 25, 75 and 225 ㎎/㎏/day, respectively. In human study, the test article was administered orally every day for 8-week at a dose of 1,500 ㎎/㎏, tid and placebo group. The blood glucose levels (BGL) at 0.5 hour after treatment are significant decreased in all treatment groups of OGTT test. In the 4-week test, BGL of 75 and 225 ㎎/㎏/day group is continuously decreased during all treatment periods and the BGL of 25 ㎎/㎏/day group show decreasing trends at the final week, the pancreas weight of all treatment groups are being increased, and the Langerhans-islet numbers were increased at all treatment groups with a dose-response manner. There are no test article-related abnormal signs and the fasted blood glucose (FBG), postprandial blood glucose (PPG) and HbA1c are decreased significantly after 8-week treatments. These results that the cultured mycelia from Ganoderma applanatum could decrease BGL by protecting the degeneration of Langerhans islets.

Composite membranes were prepared by the deposition of pentafluoropyridine(PFP) or pentafluorotoluene(PFT) plasma films onto porous Celgard and nonporous poly(dimethylsiloxane) [PDMS] films. Gas permeation measurements for the composite membranes were made in the temperature range of 35˚C to 75 ˚C and the solubilities in plasma polymers were measured using a Cahn Microbalance. The permeability coefficients of plasma polymers obeyed the Arrhenius relationship fairly wall. Activation energies for permeation in the plasma films increased with the size of penetrant molecules. The activation energy of plasma polymers was much lower than that of commonly used perfluoropolymers. This difference was proved to be attributable to the much lower heat of solutions of the plasma polymers compared to perfluoropolymers. The diffusion activation energies were comparable with each other.