Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy. Numerous therapies have been proposed for its cure. Research is continually being conducted to develop new forms of treatment as current therapies are associated with numerous side-effects. Luteolin, a common dietary flavonoid, has been demonstrated to possess strong anti-cancer activity against various human cancer cell lines. Nevertheless, research into luteolin-based anticancer activity against oral cancer remains scarce. Thus, the objective of this study was to assess the effect of luteolin as an anti-cancer agent. After treatment with luteolin, Ca9-22 and CAL-27 oral cancer cells showed condensed nuclei and enhanced apoptotic rate with evidence of mitochondria-mediated apoptosis. Epithelial-mesenchymal transition (EMT) is closely related to tumor migration and invasion. Luteolin suppressed cancer cell invasion and migration in the current study. Elevated expression of E-cadherin, an adherens junction protein, was evident in both cell lines after luteolin treatment. Luteolin also significantly inhibited transcription factors (i.e., N-cadherin, Slug, Snail, Twist, and ZEB-1) that regulated expression of tumor suppressors such as E-cadherin based on Western blot analysis and quantitative PCR. Thus, luteolin could induce mitochondrial apoptosis and inhibit cancer cell invasion and migration by suppressing EMT-induced transcription factors.

조명나방의 유충성장(幼蟲成長)에 따른 탄수화물대사(炭水化物代謝)의 변화(變化) 및 혈림프와 충체(蟲體)내 항상성(恒常性)을 구명(究明)키 위해 Glucose, Trehalose 그리고 Glycogen을 측정한 결과는 다음과 같다. 헐림프내 Glucose는 3령유충에서 최고함량(最高含量)을 나타냈으며 4령유충에서 급격히 감소(減少)하다가 종령유충으로 성장(成長)하면서 다시 증가(增加)하였고, 충체(蟲體)에서는 유충기(幼蟲期) 성장과정동안 서서히 감소(減少)하는 현상(現象) 나타냈다. Trehalose는 혈림프에서 유충기의 성장과 더불어 증가하면서 높은 함량을 나타낸 반면, 충체(蟲體)에서는 낮은 함량을 보였다. Glycogen은 혈림프에서 Trehalose와 같은 패턴으로 증가하였으나, 충체(蟲體)내에서는 Trehalose와 반대현상(反對現象)을 나타내면서 증가하였다.

Purpose: In this study, we would like to confirm that the transfer of young workers may be a means of enhancing their internal satisfaction, not to get a better job, by setting work-related characteristics that are highly relevant to job-related factors. Research design, data, and methodology: In this study, preparation for turnover was set as dependent variables to identify factors related to the turnover of young people, and the type of business, employment type, debt status, job satisfaction, job difficulty compared to education level, job difficulty, job degree, job major agreement, debt status, and other demographic social characteristics were selected as independent variables. Results: The characteristics related to personal criteria in job-seeking process were significant in the form of business, employment type, job satisfaction, work difficulty compared to the level of education, work difficulty compared to the level of technology, job major matching, and debt status. Conclusions: This study confirmed that young people's turnover may not simply be a means to get a better job, but to increase satisfaction in the internal aspects of their jobs, and that for young people, a job is an important development process that represents their identity and needs to be approached from a life-cycle perspective.

This study examines how economic preparation for later life directly influences life after retirement. As people’s life cycle is gradually getting longer, preparation for the later time with less economic activity after retirement is becoming more important. Thus, this study analyzes the factors influencing life after retirement. Data comes from the Korean Retirement and Income Study (KReIS) surveyed carried out by the National Pension Research Institute in 2015. The analysis includes Cronbach’s alpha, Pearson Product Moment Correlation Coefficient and Sobel Test. This study confirms that voluntary retirement has a positive influence on life satisfaction. Results are in line with previous research about the relationship between voluntary retirement and retired life. When a person retires voluntarily, financial preparation can be made in advance for retirement. In case of involuntary retirement, people may experience a sense of loss in personal standing and financial difficulties due to the unexpected situation. Especially, early retirement from the main workplace leads to unstable later life. The study’s policy recommendation, in particular, calls on government and businesses to agree on social responsibility for helping employees to retire in the predictable retirement time and, thus, enabling the retiree to decide all aspects of the path after retirement.

Purpose - In this study, we would like to analyze how the general characteristics of retired senior citizens affect directly the satisfaction of retirees' lives. As the life cycle continues to grow longer, post-retirement environment is recognized as important, and this study is conducted to analysis the factors that concerns which parts influence future retirement life. Research design, data, and methodology - First, Pearson’s correlation analysis was conducted to analyze the correlation between the satisfaction of retirement life and the characteristics of the elderly. Secondly, a one-way analysis of variance was conducted to find out the difference in the satisfaction level of post-retirement life depending on the characteristics of the elderly. Results - First, the demographic factors for the satisfaction of retirement life have shown a definite difference. Second, the family factors for the satisfaction of retirement life have shown a clear difference. Third, financial factors for the satisfaction of retirement life have shown a clear difference. Conclusions - Early retirement, especially in major jobs, is the basis for incomplete retirement preparation, which is a factor in unstable later life. If a prospective retiree can retire in a predictable retirement age, it would be sufficient to prepare for retirement in various areas, or to prepare for further directions.

Purpose - This study is intended to explore influential factors on the life satisfaction of physically challenged laborers preparing for support plans for their future. This is to enjoy a better life and have social opportunities and to review institutional support or plans for implementation to be applied for physically challenged people. Research design, data, and methodology - 4,161 disabled people participated in the Panel Survey of Employment of the Disabled. Among 2,124 physically challenged people, 957 wage workers (45%) were primarily extracted in this study, and a total of 581 (27%) with sufficient responses on the questionnaires were finally selected. Results - First, physical preparation for later life had a positive influence on retired life satisfaction among retirement satisfaction. People showed higher retired life satisfaction. Secondly, physical preparation for later life had a positive influence on satisfaction over relationship after retirement among retirement satisfaction. Conclusions - In this study, , it was found that job satisfaction was the variable with the highest influential power on life satisfaction. Therefore, it seems to be necessary to proceed a research as to which factors influence life satisfaction in the medium of job satisfaction and also about plans to improve job satisfaction on experts or the disabled.

Purpose - This study is to verify the mediating effect of voluntariness in retirement and the moderating effects of leisure life to examine which parts of later life preparations have influence on the retired life. Research design, data, and methodology - In this study, the 6th Korean Retirement and Income Study was conducted on 5,254 members of households with householders over the age of 50. To examine the relationship between later life preparation and retired life, this study used personal data based on the serial number of the household members. Results - First, physical preparation for later life had a positive influence on retired life satisfaction among retirement satisfaction. People showed higher retired life satisfaction. Secondly, physical preparation for later life had a positive influence on satisfaction over relationship after retirement among retirement satisfaction. People showed higher satisfaction over relationship after retirement when they were more physically prepared for later life. Conclusions – In particular, leisure life had a mediating effect for the influence of physical preparation for later life on the retired life. Also, leisure life and physical preparation for later life showed a close influencing relationship. People showed active leisure life and higher retired life satisfaction when they were more physically prepared for later life.

Purpose – The purpose of this research is to verify mediation effects of finance stress within relation structure between income inequality recognized by the elderly and life satisfaction. Research design, data, and methodology - In order to achieve the purpose of this research, we investigated recognition of income inequality of the elderly, finance stress and life satisfaction by using examination data aimed at 541 elderly people whose age is over 65 living in Chungcheongbuk-do. We conducted reliability, correlation, regression analysis_(tolerance limit and variance inflation factor) by using SPSS ver. 18.0. Results – From the result of analysis, it was proved that there are mediation effects of finance stress within the relation between income inequality recognized by the elderly and satisfaction with life. Based on this result, we suggest practical and political proposals to increase life satisfaction of the elderly. Conclusions - The purpose of this research is to verify mediation effects of finance stress in the relationship between income inequality and life satisfaction recognized by the elderly. From the result of research, first, a direct effect was discovered that as income inequality becomes high, life satisfaction will be decreased. Second, partial mediation effect of finance stress was confirmed in the relationship between income inequality and life satisfaction.

Purpose - This study aims to determine whether history education for Korean-Chinese living in Korea affects their understanding for Korean society. It also aims to determine Korean-Chinese compatriots to recognize the necessity for History education. Research design, data, and methodology – In this study, two parts were examined, which were the analysis on the influence of history education and the Korean-Chinese compatriots’ adaptation to Korean society. In the case of data survey, Korean-Chinese compatriots were selected who are living in Korea. The survey was conducted using the samples of 200 questionnaires in total. Results - The results of the analysis shows that their residence adaptation in Korea has a positive impact on future nationality. Moreover, the residence adaptation in Korea has positive implications for their future nationality and their longer residence duration in Korea has an effect on their hope for living in Korea. Conclusions - The study showed the historical consciousness and related demographic characteristics of Korean compatriots living in Korea. It also showed that the longer their education duration for Korean history in China, the more difficult their adaptation would be. Therefore, the long term effects of adaptation depended on the emphasis of Korean history.

Purpose - This study aims to analyze the effects of the social support on the economic activities from the Korean Chinese residing in Korea. Particularly, this paper focuses on the consequence of the economic activity intention according to the three kinds of social support. Research design, data, and methodology - For the statistics process of data collected by this survey, SPSS 19 statistics package program was used through data-coding and data-cleaning processes to analyze the data in this study. Results - This hypothesis was selected partially. As a result of investigating hypotheses in detail, Hypothesis 1-2 was significant as shown in the significance level 0.1, and when the emotional support was regarded important, the will of economic activities was also higher. Hypothesis 1-2 was found to be meaningful with the significance level of 0.05, and when the social support was regarded important, the will of economic activities was also higher. Lastly, Hypothesis 1-3 was found to not be statistically significant. Conclusions - The results of this study are expected to be used as basic data for vitalization of the Korean Chinese’ economic activities and governmental support for it, and to be a guideline in preparing successful strategies for expansion of the Korean Chinese’ economic activities in the future by applying these results.