This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.

In this study, standard precipitation index- based analysis associated with run theory was performed using 53 years’ (1967– 2019) precipitation data to investigate the meteorological drought in Chuncheon. The duration of the meteorological drought in Chuncheon was 8.06 months, magnitude of the drought was -8.21, and average drought depth was -1.08. The drought in May 2014 lasted 21 months until January 2016; the drought scale and average depth was -34.06 and -1.62, respectively. This was the most severe drought in Chuncheon. As a result of drought frequency analysis, the drought scale of May to December in 2014 was estimated to be -16.16, and the return period was estimated to be 300 years. These results are expected to further increase the magnitude and frequency of weather droughts caused by climate change. Therefore, it is critical to prepare appropriate structural measures.