This perspective article delves into the evolving landscape of non-viral vectors for efficient CRISPR delivery, addressing the challenges associated with viral vectors and highlighting the potential of carbon-based nanomaterials as promising alternatives. The article underscores the importance of design strategies in enhancing the interactions between CRISPR components and carbon-based nanomaterials. Various design approaches are explored, including the incorporation of modified nanoparticles between carbonic layers and the creation of unique morphologies to facilitate optimal CRISPR interactions. Specific case studies are presented to exemplify the effectiveness of carbon-based nanomaterials in CRISPR delivery. This perspective sheds light on the dynamic field of non-viral CRISPR delivery vectors, emphasizing the significance of design strategies and showcasing the promising outcomes achieved through the utilization of carbon-based nanomaterials. The provided insights contribute to the ongoing efforts to develop efficient and safe methods for gene delivery and therapy.