Structural inversion refers to the reverse reactivation of extensional faults that influence basin shortening accommodated by contractional faults or folds. On the Korean peninsula, Miocene inversion structures have been found, but the Cretaceous rocks on Geoje Island may have undergone inversion as early as the Upper Cretaceous. To evaluate the structural inversion on Geoje Island, located on the eastern side of South Korea, and to determine the effects of preexisting weakness zones, field-based geometric and kinematic analyses of faults were performed. The lithology of Geoje Island is dominated by hornfelsified shale, siltstone, and sandstone in the Upper-Cretaceous Seongpori formation. NE and NW-oblique normal faults, conjugate strike-slip (NW-sinistral transpressional and E-W-dextral transtensional) faults, and NE-dextral transpressional faults are the most prominent structural features in Geoje Island. Structural inversion on Geoje Island was evidenced by the sinistral and dextral transpressional reactivation of the NW and NE-trending oblique normal faults respectively, under WNW-ESE/NW-SE compression, which was the orientation of the compressive stress during the Late Cretaceous to Early Cenozoic.

To preserve the superior genetic resources and restore the endangered species, Somatic cell nuclear transfer (SCNT) has been used widely. In Korea, the research of dog cloning has made outstanding achievements including the production of the world`s first cloned dog. Sapsaree (Sapsalgae), the representative dog of Gyeongsan-si was designated as a Korea natural monument (No. 368). This male dog used in this study has azoospermia due to unknown cause. In this study, the aim was to confirm the cause of infertility in the cell donor dog and to evaluate the reproduction potential of dog cloning using infertile male dog by SCNT. First, to confirm the infertility of the cell donor dog, the reproductive history and the testis were evaluated. The breeding histology was not recorded in individual document. In histopathology, the Sertoli cell tumor was confirmed in biopsy of the cell donor dog after death. But, these tumors are predominantly in older dogs. Second, we produced the cloned dogs with the somatic cells of the infertile dog and the appearance was similar with the cell donor dog. Also, microsatellite analysis confirmed the genetic relationship between the cell donor and clone dogs. Third, the potential breeding capacity of the cloned dog was confirmed. In T4 assay, the normal dog (same age with cloned dogs), cell donor dog, and cloned dogs was investigated. The cell donor dog with azoospermia had very low T4 level, and cloned dogs showed higher level of T4 than normal dogs. In CASA, There was no significant difference in sperm motor ability between normal dogs and cloned dogs. As a result, cloned dogs produced by SCNT had no problem regarding the reproductive function of the testis. In AI experiment, the semen of clone dogs was used to fertilize a natural female bitch and was diagnosed pregnancy by ultrasonography. In total, 7 puppies were born by normal delivery (male: 3, female: 4). In conclusion, this study confirmed that the reproduction problem of non-genetic infertility can generate a normal descendant by SCNT. Also, the first successful research to restore infertile dogs was completed. Furthermore, SCNT would be useful for the restoration of endangered species and application of superior traits.

[6]-Gingerol, a major polyphenol of ginger(Zingiber officinale), exhibits a variety ofbiological properties including anti-oxidant, anti-inflammatory and anti-cancer activity. However,the radioprotective effect of [6]-gingerol is still unknown. The aim of this study was to investigatethe radioprotective effect of [6]-gingerol against radiation-induced cell cytotoxicity and oxidativestress in HepG2 cells. [6]-Gingerol pretreatment attenuated radiation-induced cell cytotoxicitycaused by 5Gy(half lethal dose, LD50of HepG2 cells). The measurements of superoxide dismutase(SOD) and catalase(CAT) activity were also performed. The results showed that [6]-gingerol pre-treatment reduced increasing SOD and CAT activity after exposure of IR, indicating that [6]-gin-gerol protected oxidative stress by regulating cellular antioxidant enzyme(SOD and CAT) activity.These findings suggest that [6]-gingerol acts as a radioprotector by attenuating cell cytotoxicityand oxidative stress.