Periodontitis and periimplantitis are caused as a result of dental biofilm formation. This biofilm is composed of multiple species of pathogens. Therefore, controlling biofilm formation is critical for disease prevention. To inhibit biofilm formation, sugars can be used to interrupt lectin-involving interactions between bacteria or between bacteria and a host. In this study, we evaluated the effect of D-Arabinose on biofilm formation of putative periodontal pathogens as well as the quorum sensing activity and whole protein profiles of the pathogens. Crystal violet staining, confocal laser scanning microscopy, and scanning electron microscopy revealed that D-Arabinose inhibited biofilm formation of Porphyromonas gingivalis , Fusobacterium nucleatum , and Tannerella forsythia . D-Arabinose also significantly inhibited the activity of autoinducer 2 of F. nucleatum and the expression of representative bacterial virulence genes. Furthermore, D-Arabinose treatment altered the expression of some bacterial proteins. These results demonstrate that D-Arabinose can be used as an antibiofilm agent for the prevention of periodontal infections.

In spite of a short history of only 30 years in space development, Korea has achieved outstanding space development capabilities, and became the 11th member of the “Space Club” in 2013 by launching its own satellites with its own launch vehicle from a local space center. With the successful development and operation of more than 10 earth-orbiting satellites since 1999, Korea is now rapidly expanding its own aspirations to outer space exploration. Unlike earth-orbiting missions, planetary missions are more demanding of well-rounded technological capabilities, specifically trajectory design, analysis, and navigation. Because of the importance of relevant technologies, the Korean astronautical society devoted significant efforts to secure these basic technologies from the early 2000s. This paper revisits the numerous efforts conducted to date, specifically regarding flight dynamics and navigation technology, to prepare for future upcoming planetary missions in Korea. However, sustained efforts are still required to realize such challenging planetary missions, and efforts to date will significantly advance the relevant Korean technological capabilities.