The cruise industry in the Mediterranean region increased from 2000-2018, being the second most important region after the Caribbean. The purpose of this study was to analyze the networks and hub ports of the Mediterranean. This paper used the SNA (Social Network Analysis) methodology, which includes Hub and Authority Combined Centrality (HACC) that has been used to analyze cruise port centrality, as well as degree centrality such as In-Degree, Out-Degree, and Betweenness. This empirical study suggests that the top three ports of the Mediterranean ports’ network in terms of hub index are Barcelona, Civitavecchia, and Palma de Mallorca. The academic implications are the suggestion for data integration based on real itineraries and numbers of POC (Port of Calls), as well as the selection of the hubs of the targeted areas. The practical implications are suggested such as a clear requirement for cruise industry, as a way to widen the scope for the Mediterranean region and a valuable reference for cruise ship companies to select the best fit home ports.