Understanding the distribution of heavy metals in sediment is necessary because labile heavy metals can partition into the water column and bioaccumulate in aquatic organisms. Here we investigated six heavy metals (Co, Cu, Mn, Ni, Pb, and Zn) in sediment cores using a five-step sequential leaching method to examine the occurrence of heavy metals in the sediment. The results showed that all elements, except Mn, are depleted in the exchangeable and carbonate fractions. However, heavy metal concentrations are much higher in the Fe-Mn oxide and organic matter fractions, especially for Cu, indicating enrichment in the organic matter fraction. Furthermore, contamination parameters (contamination factor and geoaccumulation index) indicate that Mn contamination is high, primarily derived from anthropogenic sources, presenting a potential risk to ecosystems in the Nakdong River.

최근 소프트웨어 유통망(ESD)를 통해 유통되는 게임이 늘어남에 따라 사용자들이 원하는 게임을 찾는데 어려움을 겪고 있다. 이에 따라 사용자들이 원하는 게임을 찾기 쉽게 태그를 생성하는 모델의 필요성이 대두 되고 있다. 본 논문에서는 태그를 생성하는 모델을 BERT를 통해 설계하였다. 태그 100개 중 가장 적합한 태그를 4개 추출하기 위해 입력된 문장에 대해 각 태그별로 이진분류를 수행하고 이진분류 당시의 Softmax 값이 가장 컸던 태그 4개를 선택했다. 또한, 모델의 정확도를 위해서 약 33억 개의 다국어 단어로 학습한 pre-trained Multilingual BERT 모델과 약 5천만 개의 한국어 단어로 학습한 KoBERT 모델을 가져와 한국어 데이터로 학습(finetuning) 시켜 사용하였다. 실험에서 BERT 모델은 KoBERT 모델보다 F- 점수에서 9.19 % 더 나은 성능을 보입니다. 이는 언어 학습 데이터 세트의 크기가 특정 언어인 한국어 특성보다 더 중요하다는 것을 나타낸다.

Alpha-lipoic acid (ALA) is a naturally occurring antioxidant and has been previously used to treat diabetes and cardiovascular disease. However, the autophagy effects of ALA against oxidative stress-induced dopaminergic neuronal cell injury remain unclear. The aim of this study was to investigate the role of ALA in autophagy and apoptosis against oxidative stress in the SH-SY5Y human dopaminergic neuronal cell line. We examined SH-SY5Y phenotypes using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay (cell viability/proliferation), 4′,6-diamidino-2-phenylindole dihydrochloride nuclear staining, Live/Dead cell assay, cellular reactive oxygen species (ROS) assay, immunoblotting, and immunocytochemistry. Our data showed ALA attenuated hydrogen peroxide (H2O2)-induced ROS generation and cell death. ALA effectively suppressed Bax up-regulation and Bcl-2 and BclxL down-regulation. Furthermore, ALA increased the expression of the antioxidant enzyme, heme oxygenase-1. Moreover, the expression of Beclin-1 and LC-3 autophagy biomarkers was decreased by ALA in our cell model. Combined, these data suggest ALA protects human dopaminergic neuronal cells against H2O2-induced cell injury by inhibiting autophagy and apoptosis.

We report the structural characterization and electric heating performance of carbon thin films (CTFs), which were prepared from negative-type SU-8 photoresist by deep UV exposure and following carbonization. The prepared CTFs were found to have pseudo-graphitic carbon structures containing partially graphite domains in the amorphous carbon matrix. The CTFs showed a very smooth surface morphology with a roughness of 0.42 nm. The 107 nm-thick CTFs exhibited an excellent electric heating performance by attaining a high maximal temperature of 207 °C and a rapid heating rate of 13.2 °C/s at an applied voltage of 30 V. Therefore, the CTFs prepared in this study can be applied as electrode materials for high-performance electric heaters.