This study was performed to assess particulate matter removal efficiency of domestic air cleaner products in a field condition. The assessment also included air cleaners with different air removal mechanisms. The particulate matter (PM2.5) removal test with a different air removal mechanism using air cleaners showed that the electrostatic precipitation technique showed better performance compared with HEPA filters and other types of systems. Its removal efficiency was almost 95% in one of our operation times in the given test condition. It was assumed that not only the type of removal system but also the individual design, supply and exhaust system, and the automatically controlled air volume are involved in the removal efficiency. With respect to the area of application, tests with air cleaners for 40 m2, 60 m2, and 80 m2 areas revealed that particulate matter removal efficiency increased with the air cleaner that had a broad area of application. However, particulate matter removal efficiency by air cleaners did not correspondingly increase with the increase of the area of application. Moreover, the installation location did not influence particulate matter removal efficiency. Our results are expected to be used as the basic information for indoor air quality improvement and prediction using air cleaners.