We present a case of cellular angiofibroma arising from right neck in a 46-year-old woman. Surgical excision was performed and the patient was disease free till now. Cellular angiofibroma usually arised in the inguinoscrotal of vulvovaginal regions. Only 3 cases of cellular angiofibroma involving maxillofacial region have been reported in the english written literature. Cellular angiofibromas are rare benign tumor characterized by bland spindle shaped cells arranged in a stroma with wispy collagen and numerous vessels. Immunohistochemical stains of the tumor cells showed the positivity for CD34, PR, EMA, but negativity for neurofilament, desmin and actin. The tumor should be differentiated from aggressive angiomyxoma and angiomyofibroblastoma, angiofibroma because of its clinical and histological similarity. We report a rare case of benign cellular angiofibroma involving right neck and study other published articles.

Cellular angiofibroma is a benign mesenchymal tumor with uniform, bland, spindle cell differentiation accompanied by thick walled vessels. We report a 17-year-old male who was diagnosed cellular angiofibroma on his right spermatic cord. He had small (about 1cm sized), non-tender, painless, movable mass for 3 years but 1 year ago insidious size of mass increased. Histological finding showed features characteristic of cellular angiofibroma however that occurs almost exclusively in vulvar of middle aged women. In addition, benign mesenchymal neoplasms had similar histologic findings with angiofibroma, especially aggressive angiofibroblastoma, aggressive angiomyxoma and solitary fibrous tumor. Specific immunohistochemical stain profile of angiofibroma helpful of differential diagnosis. Local excision with clear resection margin and long-term follow up are the treatment of choice as local recurrence has been reported in a few case.