본 연구는 관절통 모델에서 웅담 우황과 웅담 우황 사향의 약침액의 효과를 검사하기 위해 수행되었다. 할로탄 마취하에서 관절통은 수컷 쥐의 관절강내에 2% carrageenan을 주입하여 유발시켰다. 운동자극에 대한 감각신경의 반응은 약침을 시술하기 전과 후에 기록하였다. 경혈에 주입한 약침은 유해한 운동 자극에 대한 신경의 반응을 억제시켰다 족삼리에 시술한 약침은 합곡에 비해 유해한 자극에 대한 관절 감각신경의 반응을 더 많이 억제시켰다. 이러한 결과는 웅담 우황과 웅담 우황 사향의약침이 관절통을 완화하는 데 효과적인 치료법을 제공할 수 있다는 것을 시사한다.

This study was performed to prove the antithrombotic effects of paeonia japonica (赤芍葯, PJ) aqua-acupuncture solution by way of experimental methods. the thrombosis was induced by injection of collagen the mixture (0.1ml/10g, 2mg/kg B.W) plus serotonin (5mg/kg B.W) into the caudal vein of rats, 2 hours after liquid extract of paeonia japonica (PJ) was acupunctured into 'Taechung' (太衝:Liv3) of rats. The effect of aqua- acupunctures of paeonia japonica (PJ) was examined by the number of RBC and platelets, bleeding time, blood clotting time, death rate, platelet aggregation, plasma coagulation factor activity, exvivo and vitro fibrinolytic activicty of englobulin fracture in the rats. The results were summerized as followings. 1. The number of RBC and platelets was significantly increased in PJ-treated group in comparison with the control group. 2. Bleeding time was significantly shortened in PJ-treated group in comparison with the control group. 3. Blood clotting time was significantly prolonged in PJ-treated group in comparison with the control group. 4. The death rate of mouse was inhibited in PJ-treated group in comparison with the control group. 5. The platelet aggregation was inhibited in PJ-treated group in comparison with the control group. 6. The prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity was prolonged but was not valuable in PJ-treated group. 7. Fibrinogen lyses time of rat was reduced and lyses area was increased in PJ-treated group in comparison with the control group. 8. Fibrinogen lyses time of rat in vitro assay was reduced in PJ-treated group. From the above results, it was thought that the aqua-acupuncture of PJ could be applied effectively in the thrombosis.