Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. Accumulating evidence indicates that Se compounds possess anticancer properties. Se is specifically incorporated into proteins in the form of selenocysteine and non-specifically incorporated as selenomethionine in place of methionine. This study evaluated protection by Se in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Sprague-Dawley rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of X-rays on the lower limb region. The animals were euthanized at 7, 15, 22 and 29 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/ Se and Ov/Se/Irr groups. Our findings suggest that sodium selenite may influence a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity.

이 연구에서는 24마리의 Japanese White 토끼를 대상으로 양쪽 비골을 인위적으로 골절시킨 후 초음파치료가 골절의 치유에 효과가 있는지를 알아보았다. 초음파 치료 후 대조군의 비골과 실험군의 비골에서의 골소주 비율은 차이가 없었으며 초음파 주파수를 0.875 MHz로 하였을 때와 3 MHz로 하였을 때의 골소주 비율도 차이가 없었다. 따라서 초음파 치료는 토끼의 비골 골절의 치유 효과가 없었다. 그러나 다양한 주파수와 초음파 전달양식을 변화시켰