Kaposi’s sarcoma is one of the first recognized in HIV infection even patient can develop KS in any disease stage. Moreover, the oral cavity may be the first site of Kaposi’s sarcoma and oral mucosa involvements of KS in HIV positive are very critical because it had a higher death rate than those who having exclusively cutaneous manifestations of the disease. Early detection of KS oral involvement is very important to prevent disease burden. This case is about a 48 years old male who was first discovered Oral Kaposi’s Sarcoma as HIV infection sign. He didn’t notice any other discomfort other than oral mucosa swelling.

Kaposi's sarcoma is a lympho-angioproliferative disease that primarily affects the skin and subcutaneous tissues. Most importantly, Kaposi’s sarcoma occurs in the immunocompromised, especially AIDS patients and organ transplant recipients being treated with immunosuppressants. The occurrence of classic Kaposi’s sarcoma after the diagnosis of any primary solid tumor has rarely been reported. We experienced a 70-year-old man, who had received surgery and chemoradiotherapy for the treatment of primary gallbladder cancer, that developed multiple tender deep purple papules on his trunk, back and feet which were proven to be pathologic symptoms of Kaposi’s sarcoma.