This study introduces and experimentally validates a novel approach that combines Instruction fine-tuning and Low-Rank Adaptation (LoRA) fine-tuning to optimize the performance of Large Language Models (LLMs). These models have become revolutionary tools in natural language processing, showing remarkable performance across diverse application areas. However, optimizing their performance for specific domains necessitates fine-tuning of the base models (FMs), which is often limited by challenges such as data complexity and resource costs. The proposed approach aims to overcome these limitations by enhancing the performance of LLMs, particularly in the analysis precision and efficiency of national Research and Development (R&D) data. The study provides theoretical foundations and technical implementations of Instruction fine-tuning and LoRA fine-tuning. Through rigorous experimental validation, it is demonstrated that the proposed method significantly improves the precision and efficiency of data analysis, outperforming traditional fine-tuning methods. This enhancement is not only beneficial for national R&D data but also suggests potential applicability in various other data-centric domains, such as medical data analysis, financial forecasting, and educational assessments. The findings highlight the method's broad utility and significant contribution to advancing data analysis techniques in specialized knowledge domains, offering new possibilities for leveraging LLMs in complex and resource- intensive tasks. This research underscores the transformative potential of combining Instruction fine-tuning with LoRA fine-tuning to achieve superior performance in diverse applications, paving the way for more efficient and effective utilization of LLMs in both academic and industrial settings.