The purpose of this study is to explore how adolescents' psychological characteristics affect their sense of life safety according to gender. To this end, a survey was conducted on male and female high school students in six schools in the C area, and a total of 1,048 data were used for analysis. Differences in major variables according to gender were verified, and the effect of psychological characteristics on living safety awareness was analyzed through hierarchical multiple regression analysis. As a result of the analysis, depression, anxiety, type A characteristics, and the presence or absence of experience in accidents did not significantly affect life safety awareness in the male student group. On the other hand, in the female student group, anxiety and type A characteristics had a significant effect on life safety awareness. Anxiety negatively affects living safety awareness, and type A characteristics have been shown to have a positive effect on living safety awareness. The presence or absence of depression and accident experience did not significantly affect life safety awareness. The results of these studies suggest that gender differences should be considered in education to prevent life safety awareness and that education that reflects the psychological characteristics of adolescents is necessary.